Validation of Disease States in Schizophrenia: Comparison of Cluster Analysis Between the United States and European Populations
2013 Value in health
Thokagevistk, K. | Millier, A. | Lenert, L. | Sadikhov, S. | Moreno, S. |
analysis, Disease, Schizophrenia, United States,
A set of disease states for patients with schizophrenia was previously published using a statistical clustering method, applied to Positive and Negative Syndrome Scale (PANSS) data from US patients. While factor analyses of the PANSS have shown remarkable stability of the structure across international populations, it is unknown whether similar multidimensional disease states would also be stable. Using data from the European Schizophrenia Cohort (EuroSC), a 2-year observational study in 1,208 schizophrenia patients, we examined the factor structure of the PANSS and identified disease states using the same clustering method as previously.