Side-effects of antipsychotic medication and health-related quality of life in schizophrenia

Side-effects of antipsychotic medication and health-related quality of life in schizophrenia

2009 Acta Psychiatr. Scand. Suppl

Bebbington, P.E. | Angermeyer, M. | Azorin, J.M. | Marwaha, S. | Marteau, F. | Toumi, M. | Volume: , Issue: 438, Pages: 22-28, Adult, adverse effects, analysis, Antipsychotic Agents, Basal Ganglia Diseases, Body Weight, chemically induced, Cholinergic Antagonists, Chronic Disease, Cohort Studies, diagnosis, drug effects, drug therapy, Follow-Up Studies, Health Status Indicators, Humans, Male, Middle Aged, psychology, Quality of Life, Schizophrenia, Schizophrenic Psychology, Sexual Behavior, Sialorrhea, therapeutic use, Young Adult,

OBJECTIVE: This analysis used data from the large (n = 1208) European Schizophrenia Cohort to examine the association between subjective side-effects of antipsychotic medication and the Mental and Physical Composite Scores (MCS; PCS) of the SF-36 scale. METHOD: Relationships between the subjective evaluation of side-effects identified from the Subjective Side-Effects Scale and the adjusted mean score on the PCS and MCS were examined. Where appropriate, these associations of subjective side-effects were compared with those of the same side-effects measured objectively. RESULTS: In this study, subjective side-effects of antipsychotic medication were linked either to both the PCS and the MCS or, in a few instances, to neither. Subjective evaluations of sexual side-effects were associated only with the MCS, those of sialorrhoea only with the PCS. Objective ratings of extrapyramidal side-effects were related neither to PCS nor to MCS. CONCLUSION: These data suggest that side-effects, whether subjective or objective, may need to be considered individually in relation to their impact on quality of life

https://www.doi.org/10.1111/j.1600-0447.2008.01310.x