[PRS9] Evolution Of Tiotropium Efficacy Vs. Placebo Over Time For The Maintenance Therapy Of Chronic Obstructive Pulmonary Disease: From Investigational Product To Active Reference

[PRS9] Evolution Of Tiotropium Efficacy Vs. Placebo Over Time For The Maintenance Therapy Of Chronic Obstructive Pulmonary Disease: From Investigational Product To Active Reference

2015 Value in Health

Thokagevistk, K. | Khemiri, A. | Dorey, J. | Toumi, M. | Volume: 18, Issue: 7, Pages: A495,

Previous studies have demonstrated substantial variation of the relative efficacy of widely used drugs over time. Changes in population characteristics or variation in the placebo response may be potential influencers. We used tiotropium as a treatment to examine this phenomenon as it has commonly been used as a reference treatment over time in Chronic Obstructive Pulmonary Disease (COPD). We aimed to assess the evolution of the relative efficacy of inhaled tiotropium against placebo, between launch and the latest assessment.

https://www.doi.org/10.1016/j.jval.2015.09.1384