Sofosbuvir, a breakthrough anti-HCV (hepatitis C virus) polymerase inhibitor, was first approved for early entry in 2012 in France. The product was granted a marketing authorisation in the United-States (US) and in the European Union (EU), by the end of 2013 and beginning of 2014, respectively. Shortly after licensing, most HTA bodies assessed sofosbuvir; they acknowledged a major additional benefit and find it cost-effective for a price around USD 80,000 in US and USD 55,000 in EU for a 12-week course treatment