Meta-analyses using real-world data to generate clinical and epidemiological evidence: a systematic literature review of existing recommendations

Meta-analyses using real-world data to generate clinical and epidemiological evidence: a systematic literature review of existing recommendations

2018 Curr Med Res Opin

Briere, J. B. | Bowrin, K. | Taieb, V. | Millier, A. | Toumi, M. | Coleman, C. | Volume: 34, Issue: 12, Pages: 2125-2130, Bias, Guidelines, Meta-analysis, Real-world evidence, Systematic review,

OBJECTIVES: To identify existing guidelines, key recommendations, and existing limitations regarding the evaluation and use of real-world evidence (RWE) in meta-analyses (MAs) to generate clinical and epidemiological evidence: a systematic review of existing recommendations. METHODS: A literature search was performed in April 2017 in MEDLINE and Embase using the Ovid platform, the Cochrane Library, and other sources. No specific inclusion and exclusion criteria were applied, and no restrictions in timeframe, language, or geographical scope were imposed. RESULTS: The search strategy identified 1681 citations; 12 references were included in this review. Recommendations within the literature regarding the use of RWE in MAs are: (1) it may be useful to extract and analyze adjusted results because confounding is expected; (2) testing heterogeneity in the MA of RWE is important as it may minimize the potential for bias and generate hypotheses for future research; (3) limiting a search

https://www.doi.org/10.1080/03007995.2018.1524751