Measuring Treatment Effects on Rare Events Using Meta-Analysis: An Assessment of Existing Methods
2013 Value in health
Jamotte, A. | Roiz, J. |
Meta-analysis, methods, rare events,
Meta-analysis combines results from independent studies to produce robust statistical estimates. This technique is widely used in health care to synthesise treatment effects from clinical studies. However, when dealing with rare events such as rare adverse events, existing meta-analysis methods might not produce good treatment effect estimates, especially when there is no event occurrence in one or both arms of a study. The objective of this study is to compare the performance of various methods in estimating effect size for rare events.