How Should an Antidepressant with Reduced Risk of Sexual Dysfunction Be Positioned in Treatment Strategies for Patients with Major Depressive Disorder?

How Should an Antidepressant with Reduced Risk of Sexual Dysfunction Be Positioned in Treatment Strategies for Patients with Major Depressive Disorder?

2013 Value in health

Massetti, M. | Vataire, A.L. | Cristeau, O. | Toumi, M. | Aballea, S. | Volume: 16, Issue: 7, Pages: A547-A548, Depression, Depressive Disorder, Risk, Quality of Life, model, cost-effectiveness analysis, analysis,

Sexual dysfunctions (SD) is a common adverse event of antidepressants. It has a lasting impact on quality of life and is associated with an increased risk of early treatment discontinuation. Using an open-source Discrete Event Simulation model (https://open-model-mdd.org/), we performed a cost-effectiveness analysis comparing alternative sequences of treatments, to determine whether an antidepressant with moderate efficacy and reduced risk of SD should be positioned before or after a treatment with high efficacy and average risk of SD.