How Should an Antidepressant with Reduced Risk of Sexual Dysfunction Be Positioned in Treatment Strategies for Patients with Major Depressive Disorder?
2013 Value in health
Massetti, M. | Vataire, A.L. | Cristeau, O. | Toumi, M. | Aballea, S. |
Depression, Depressive Disorder, Risk, Quality of Life, model, cost-effectiveness analysis, analysis,
Sexual dysfunctions (SD) is a common adverse event of antidepressants. It has a lasting impact on quality of life and is associated with an increased risk of early treatment discontinuation. Using an open-source Discrete Event Simulation model (https://open-model-mdd.org/), we performed a cost-effectiveness analysis comparing alternative sequences of treatments, to determine whether an antidepressant with moderate efficacy and reduced risk of SD should be positioned before or after a treatment with high efficacy and average risk of SD.