Healthcare Resource Utilization Among Commercially Insured Clobazam and Non-Clobazam-Treated Patients With Lennox-Gastaut Syndrome

Healthcare Resource Utilization Among Commercially Insured Clobazam and Non-Clobazam-Treated Patients With Lennox-Gastaut Syndrome

2016 68th AAN Annual Meeting

Francois, C. | Ogbonnaya, A. | Lokhandwala, T. | Landsman, P. | Duhig, A. | Shen, V. | Volume: , Issue: , Pages: ,

Objective: The purpose of this study was to characterize healthcare resource utilization (HCRU) among commercially insured clobazam-treated patients with probable LGS and to determine HCRU pre- and post-clobazam initiation. Background: Since FDA approval in 2011, clobazam has been used as an adjunctive treatment for patients ≥2 years of age with Lennox-Gastaut syndrome (LGS). Methods: De-identified data from MarketScan® Commercial and Medicare Supplemental databases (10/1/2010 through 3/31/2014) were used to identify patients with probable LGS (≥2 medical claims for generalized convulsive or non-convulsive epilepsy and ≥1 medical claim for developmental disorder or cognitive impairment). Patients who initiated antiepileptic drug (AED) treatment with clobazam following the first claim suggestive of LGS were identified. Seizure-related HCRU in the 12 months pre-clobazam initiation was compared with HCRU in the 12 months post-clobazam initiation. Results: A total of 314 clobazam-treated patients with probable LGS and a minimum of 12-months follow-up post-treatment initiation were identified. Most patients (40.1[percnt]) were 6-12 years old (mean age = 13.2 y) and had a filled prescription for at least 1 AED prior to clobazam use [mean number of AEDs = 1.7±1.1 (SD)]. In the 12 months following clobazam initiation, significantly smaller proportions of patients were hospitalized (30.9[percnt] vs 38.2[percnt], P<0.05) or had seizure-related emergency room (18.5[percnt] vs 31.9[percnt], P <0.0001) or laboratory visits (39.5[percnt] vs 46.2[percnt], P <0.05) compared with the 12-month pre-clobazam period. Mean seizure-related hospital stays, emergency room visits, and neurologist visits post-clobazam initiation also were significantly reduced. Conclusions: Among commercially insured enrollees with probable LGS, seizure-related utilization of inpatient and outpatient services was reduced following clobazam initiation compared with an analogous period before clobazam initiation. Funded by Lundbeck, LLC