Fall-related healthcare use and costs in neurogenic orthostatic hypotension with Parkinson’s disease

Fall-related healthcare use and costs in neurogenic orthostatic hypotension with Parkinson’s disease

2017 J Med Econ

Francois, C. | Biaggioni, I. | Shibao, C. | Ogbonnaya, A. | Shih, H. C. | Farrelly, E. | Ziemann, A. | Duhig, A. | Volume: 20, Issue: 5, Pages: 525-532, Accidental Falls/*economics/*statistics & numerical data, Aged, Aged, 80 and over, Comorbidity, Emergency Service, Hospital/statistics & numerical data, Female, Health Expenditures/statistics & numerical data, Health Services/*economics/utilization, Humans, Hypotension, Orthostatic/*epidemiology, Insurance Claim Review, Male, Middle Aged, Models, Econometric, Parkinson Disease/*epidemiology, Retrospective Studies, Neurogenic orthostatic hypotension, Parkinson's disease, cost of falls, falls, healthcare costs,

AIMS: To compare patient characteristics, rates, and costs of medically attended falls among patients with Parkinson’s disease (PD) and probable PD plus neurogenic orthostatic hypotension (PD + nOH). MATERIALS AND METHODS: MarketScan Commercial and Medicare Supplemental databases (January 1, 2009-December 31, 2013) were used to identify PD and probable PD + nOH patients. The first medical or prescription claim suggesting these diagnoses served as the index date. Baseline characteristics and post-index all-cause and fall-related healthcare utilization and costs were compared between patient groups. RESULTS: A total of 17,421 PD and 281 PD + nOH patients were identified. Compared with PD patients, PD + nOH patients were older (77 vs 74 years; p < .0001) and had more comorbidities. Pre- and post-index date, more PD + nOH patients had a medically attended fall than PD patients (25% vs 20% [p = .0159] and 30% vs 21% [p = 0.0002], respectively). Fallers in both groups had similar numbers of medically attended falls 12-months pre-index (mean =1.9), but PD + nOH fallers had more falls post-index (2.5 vs 2.0; p = .0176). Compared with PD patients, more PD + nOH patients (all p < .01) had fall-related emergency department (ED) visits (18% vs 10%), hospitalizations (7% vs 3%), and non-office visit outpatient services (15% vs 10%). Adjusted total post-index medical costs for falls ($2,260 vs $1,049; p = .0002) and total all-cause costs ($31,260 vs $20,910; p < .0001) were higher for PD + nOH vs PD patients. LIMITATIONS: This study had some limitations. There is no ICD-9-CM diagnosis code for nOH, so a combination of PD and OH diagnoses (with confounding conditions excluded) served as a proxy for an nOH diagnosis. Also, the rate of falls and associated costs in these cohorts might be under-reported because only medically attended falls were evaluated. CONCLUSIONS: PD + nOH patients had a higher prevalence of pre-existing comorbidities and a higher rate of medically attended falls than those with PD alone, leading to increased costs of care.

https://www.doi.org/10.1080/13696998.2017.1284668