Breast radiotherapy as part of loco-regional treatments in stage IV breast cancer patients with oligometastatic disease

Breast radiotherapy as part of loco-regional treatments in stage IV breast cancer patients with oligometastatic disease

2010 Radiother. Oncol

Bourgier, C. | Khodari, W. | Vataire, A.L. | Pessoa, E.L. | Dunant, A. | Delaloge, S. | Uzan, C. | Balleyguier, C. | Mathieu, M.C. | Marsiglia, H. | Arriagada, R. | Volume: 96, Issue: 2, Pages: 199-203, Breast Neoplasms, Databases as Topic, Disease-Free Survival, drug therapy, Female, Follow-Up Studies, France, Humans, methods, Middle Aged, Neoplasm Staging, Neoplasms,Second Primary, radiotherapy, surgery, therapy, database analysis,

BACKGROUND: Local treatments seem to improve metastasis progression-free survival (MPFS) and overall survival (OS) when added to systemic therapies in stage IV breast cancer. METHODS: From 1990 to 2003, we reviewed 9138 cases treated and registered in the Institut Gustave-Roussy breast cancer database. Among them, 308 had presented with stage IV disease. Eighty percent of patients (n=239) had received a loco-regional treatment and they were categorized into two groups: loco-regional radiotherapy (LRRT) alone (Group 1; n=147) or breast and axillary surgery+/-LRRT (Group 2; n=92). RESULTS: The median follow-up was 6.5 years. LRRT obtained a long-standing loco-regional clinical response in 85% of patients. The 3-year MPFS rates were 20% in Group 1 and 39% in Group 2; the 3-year OS rates were 39% and 57%, respectively. However, no significant differences in MPFS or OS were observed between the two groups when adjusted on prognostic factors. CONCLUSIONS: Radiation therapy alone provides long-standing local control and yields MPFS and OS rates equivalent to those obtained when radiation therapy is combined with surgery, whatever the prognostic factors. Loco-regional therapies, especially radiation therapy alone, may have an important role to play in the treatment of selected patients with stage IV breast cancer

https://www.doi.org/S0167-8140(10)00158-1 [pii];10.1016/j.radonc.2010.02.028