Problèmes de méthodologie pour l’étude des corrélations biométéorlogiques. Le cas des crises d’asthme
1992 Risques pathologiques, rythmes et paroxysmes climatiques
Corrélations météorologiques dans l’asthme bronchique à Briançon
1992 Risques pathologiques, rythmes et paroxysmes climatiques
Le Centre Briançonnais de Recherche Bioclimatique (CBRBC): un outil au service de la bioclimatologie
1992 Climat et Santé
Le Centre Briançonnais de Recherche Bioclimatique mesure de nombreux paramètres environnementaux, recueille ces données et les exploite pour en bioclimatologie humaine
[Quantitative value of the diagnostic test for a respiratory allergy: phadiatop]
1991 TherapieHumans, Immunoglobulin E/analysis, Immunologic Tests/*instrumentation/methods, Respiratory Hypersensitivity/*diagnosis/immunology,
Altitude and allergy to house-dust mites. A paradigm of the influence of environmental exposure on allergic sensitization
1991 Am Rev Respir Dishttps://www.doi.org/10.1164/ajrccm/143.5_Pt_1.983 *Altitude, Animals, Bedding and Linens, Child, Cross-Sectional Studies, Dust/*adverse effects, *Environmental Exposure, Female, France/epidemiology, Humans, Humidity, Male, Mites/*immunology, Prevalence, Respiratory Hypersensitivity/*epidemiology, Skin Tests,
To further investigate the possibility of a cause and effect relationship between exposure to house-dust mite (HDM) allergens and respiratory disease associated with dust mite sensitivity, we compared schoolchildren living in the Alps, where exposure to HDM is low, with those living at sea level, where it is high. The study included 933 schoolchildren from the fourth and fifth grades. The protocol included the standardized 1978 American Thoracic Society (ATS) questionnaire for children, skin testing using common aero-allergens and controls, and antigenic measurements of dust samples from mattresses (Group I antigen). The prevalence of asthma with positive skin test to HDM and the overall prevalence of positive skin test to HDM were significantly lower in mountain schoolchildren. The mean geometric HDM antigenic level in mattresses was much lower in the Alps (0.36 micrograms/g dust) than at sea level (15.8 micrograms/g dust). In contrast, the prevalence of hay fever and positive skin test to grass pollens as well as the overall prevalence of positive skin tests to grass pollens were significantly higher in the Alps. These data illustrate a striking relationship between exposure to environmental allergens and atopic sensitization.
Manufacturer’s information insert and subjective theophylline side-effects
1990 Eur Respir JAdult, Asthma/drug therapy, *Drug Labeling, Female, Humans, Male, Middle Aged, Theophylline/*adverse effects/blood/therapeutic use, Treatment Refusal/*psychology,
In Western Europe medicine packages contain an insert prepared by the manufacturer which enumerates the drug side-effects. We investigated the influence of this insert on alleged theophylline side-effects. Forty literate adult asthmatics were randomly allocated into two groups (n = 20 each): theophylline packages contained the manufacturer’s insert in group A but not in group B. Theophylline was prescribed (10 mg.kg-1 body weight qd) for one week. During this period the patients filled a diary grading 13 different symptoms from 0 to 3; 5 of these symptoms were listed on the insert as theophylline side-effects. On the eighth day the patients were interviewed and theophylline blood levels measured. Theophylline side-effects were significantly more marked in group A than in group B, whereas the other symptoms were of similar magnitude. Eight patients prematurely stopped their treatment in group A vs 3 in group B, because of alleged intolerance. Theophylline blood levels did not differ significantly in the two groups; neither did they in the subgroup which stopped treatment and in the one which complied to prescription. We conclude that side-effects were suggested to the patients by the insert and/or that the insert increased their awareness of side-effects, with a subsequent detrimental influence upon compliance to therapy.
Glutathione peroxidase deficiency in patients in chronic coma treated by prolonged enteral alimentation
1990 TherapieAdult, Chronic Disease, Coma/*blood/therapy, *Enteral Nutrition, Glutathione Peroxidase/*deficiency, Humans, Middle Aged,
Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics
1990 Eur J Clin PharmacolAdult, Airway Resistance, Asthma/*metabolism, Female, Humans, Menstrual Cycle/*physiology, Protein Binding, Theophylline/*pharmacokinetics,
The effect of menstrual cycle on the pharmacokinetics of theophylline has been studied in 9 female asthmatic patients. At three different times during the cycle (first, tenth and twentieth days) each subject received an i.v. infusion of 240 mg theophylline. Significant changes were found in the kinetics of theophylline according to the menstrual cycle. The maximum plasma drug concentration, minimum mean residence time, and minimum elimination half-life were observed at mid-cycle. The lowest clearance was observed at D 20. The AUC and volume of distribution did not vary significantly during the cycle.
Antioxidant enzymes in asthmatic patients
1988 Bull Acad Natl MedAdult, Asthma/*enzymology, Erythrocytes/enzymology, Free Radicals, Glutathione Peroxidase/*blood, Humans, Superoxide Dismutase/*blood,
Asthma and allergy to house-dust mites in populations living in high altitudes
1988 Chesthttps://www.doi.org/10.1378/chest.93.4.758 Adult, *Altitude, Animals, Asthma/*epidemiology/etiology, Cross-Sectional Studies, *Dust, Female, France, Humans, Hypersensitivity/*epidemiology/etiology, Male, Middle Aged, Mites/*immunology, Skin Tests,
Do subjects living in high altitude where house-dust mites are known to be uncommon exhibit a lower prevalence of asthma and allergy to house-dust mites? To answer this question, we compared the prevalence rates of asthma and skin reactions to house-dust mites in two towns with contrasted environments: Marseille, located on the seashore, and Briancon, 1350 m in altitude. The study population consisted of a random sample of 4,008 people in Marseille and 1,055 people in Briancon. All subjects received a home questionnaire, and a sample of patients and asymptomatic subjects had a skin-prick test evaluation. The cumulative prevalence of asthma was equal to 4.1 percent in Marseille and 2.4 percent in Briancon, a difference which was significant (p = 0.01). The prevalence of positive skin tests to housedust mites in asymptomatic subjects was equal to 27.5 percent in Marseille and 10.2 percent in Briancon (p less than 0.001). This study supports the hypothesis that exposure to environmental factors may have a major influence on developing allergic diseases.